[HTML][HTML] Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1
M Jung, M Philpott, S Müller, J Schulze… - Journal of biological …, 2014 - ASBMB
Bromodomain protein 4 (BRD4) is a member of the bromodomain and extra-terminal domain
(BET) protein family. It binds to acetylated histone tails via its tandem bromodomains BD1
and BD2 and forms a complex with the positive transcription elongation factor b, which
controls phosphorylation of RNA polymerase II, ultimately leading to stimulation of
transcription elongation. An essential role of BRD4 in cell proliferation and cancer growth
has been reported in several recent studies. We analyzed the binding of BRD4 BD1 and …
(BET) protein family. It binds to acetylated histone tails via its tandem bromodomains BD1
and BD2 and forms a complex with the positive transcription elongation factor b, which
controls phosphorylation of RNA polymerase II, ultimately leading to stimulation of
transcription elongation. An essential role of BRD4 in cell proliferation and cancer growth
has been reported in several recent studies. We analyzed the binding of BRD4 BD1 and …