IL-33 exacerbates liver sterile inflammation by amplifying neutrophil extracellular trap formation
HO Yazdani, HW Chen, S Tohme, S Tai… - Journal of …, 2018 - Elsevier
Background & Aims Neutrophils and liver sinusoidal endothelial cells (LSECs) both
contribute to sterile inflammatory injury during ischemia/reperfusion (I/R), a well-known liver
surgical stress. Interleukin-33 (IL-33) has been shown to drive neutrophil infiltration during
inflammatory responses through its receptor ST2. We recently reported that infiltrating
neutrophils form neutrophil extracellular traps (NETs), which exacerbate sterile inflammatory
injury in liver I/R. Here, we sought to determine the role of IL-33 in NET formation during liver …
contribute to sterile inflammatory injury during ischemia/reperfusion (I/R), a well-known liver
surgical stress. Interleukin-33 (IL-33) has been shown to drive neutrophil infiltration during
inflammatory responses through its receptor ST2. We recently reported that infiltrating
neutrophils form neutrophil extracellular traps (NETs), which exacerbate sterile inflammatory
injury in liver I/R. Here, we sought to determine the role of IL-33 in NET formation during liver …