[HTML][HTML] Alternative intronic polyadenylation generates the interleukin-6 trans-signaling inhibitor sgp130-E10
J Sommer, C Garbers, J Wolf, A Trad, JM Moll… - Journal of Biological …, 2014 - ASBMB
Interleukin (IL)-6 signals via a receptor complex composed of the signal-transducing β-
receptor gp130 and the non-signaling membrane-bound or soluble IL-6 receptor α (IL-6R,
sIL-6R), which is referred to as classic and trans-signaling, respectively. IL-6 trans-signaling
is functionally associated with the development of chronic inflammatory diseases and
cancer. Soluble gp130 (sgp130) variants are natural inhibitors of trans-signaling. Differential
splicing yields sgp130 isoforms. Here, we describe that alternative intronic polyadenylation …
receptor gp130 and the non-signaling membrane-bound or soluble IL-6 receptor α (IL-6R,
sIL-6R), which is referred to as classic and trans-signaling, respectively. IL-6 trans-signaling
is functionally associated with the development of chronic inflammatory diseases and
cancer. Soluble gp130 (sgp130) variants are natural inhibitors of trans-signaling. Differential
splicing yields sgp130 isoforms. Here, we describe that alternative intronic polyadenylation …