Differential expression of chemokine receptor CXCR4 in Th1 and Th2 subtypes of CD4+ lymphocytes.
PP Jagodziński, WH Trzeciak - Folia Histochemica et Cytobiologica, 2000 - europepmc.org
PP Jagodziński, WH Trzeciak
Folia Histochemica et Cytobiologica, 2000•europepmc.orgDifferent cytokine profiles allow to divide the CD4+ lymphocytes into Th1, Th2 and Th0
subtypes. It has been observed that the Th2 cells are more efficient supporters for HIV-1
replication than the Th1 cells. The Th1 and the Th2 cells were isolated from peripheral blood
lymphocytes of HIV-1 seronegative individuals and the density of CXCR4 receptors was
determined by flow cytometry using antibodies directed against the CXCR4 receptor. Flow
cytometric analysis revealed higher expression of the HIV-1 co-receptor CXCR4 on Th2 …
subtypes. It has been observed that the Th2 cells are more efficient supporters for HIV-1
replication than the Th1 cells. The Th1 and the Th2 cells were isolated from peripheral blood
lymphocytes of HIV-1 seronegative individuals and the density of CXCR4 receptors was
determined by flow cytometry using antibodies directed against the CXCR4 receptor. Flow
cytometric analysis revealed higher expression of the HIV-1 co-receptor CXCR4 on Th2 …
Different cytokine profiles allow to divide the CD4+ lymphocytes into Th1, Th2 and Th0 subtypes. It has been observed that the Th2 cells are more efficient supporters for HIV-1 replication than the Th1 cells. The Th1 and the Th2 cells were isolated from peripheral blood lymphocytes of HIV-1 seronegative individuals and the density of CXCR4 receptors was determined by flow cytometry using antibodies directed against the CXCR4 receptor. Flow cytometric analysis revealed higher expression of the HIV-1 co-receptor CXCR4 on Th2 cells than on the Th1, which might explain better replication of HIV-1 viruses in the Th2 cells.
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