[HTML][HTML] Shared principles in NF-κB signaling

MS Hayden, S Ghosh - Cell, 2008 - cell.com
Cell, 2008cell.com
The transcription factor NF-κB has served as a standard for inducible transcription factors for
more than 20 years. The numerous stimuli that activate NF-κB, and the large number of
genes regulated by NF-κB, ensure that this transcription factor is still the subject of intense
research. Here, we attempt to synthesize some of the basic principles that have emerged
from studies of NF-κB, and we aim to generate a more unified view of NF-κB regulation.
The transcription factor NF-κB has served as a standard for inducible transcription factors for more than 20 years. The numerous stimuli that activate NF-κB, and the large number of genes regulated by NF-κB, ensure that this transcription factor is still the subject of intense research. Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-κB, and we aim to generate a more unified view of NF-κB regulation.
cell.com