Influence of endotoxin on graft-versus-host disease after bone marrow transplantation across major histocompatibility barriers in mice
RH MOORE, IA LAMPERT, Y CHIA, VR ABER… - …, 1987 - journals.lww.com
RH MOORE, IA LAMPERT, Y CHIA, VR ABER, J COHEN
Transplantation, 1987•journals.lww.comMuch clinical and experimental data suggest that infection and graft-versus-host disease
(GVHD) are intimately associated, and that bacterial endotoxin (ET), a potent
immunostimulant, influences the severity of GVHD. We have used a cell-wall-deficient
mutant of Escherichia coli (E coli J5) to study the effect of active and passive immunization
against ET in a murine model of GVHD induced by major histocompatibility antigens.
(GVHD) are intimately associated, and that bacterial endotoxin (ET), a potent
immunostimulant, influences the severity of GVHD. We have used a cell-wall-deficient
mutant of Escherichia coli (E coli J5) to study the effect of active and passive immunization
against ET in a murine model of GVHD induced by major histocompatibility antigens.
Abstract
Much clinical and experimental data suggest that infection and graft-versus-host disease (GVHD) are intimately associated, and that bacterial endotoxin (ET), a potent immunostimulant, influences the severity of GVHD. We have used a cell-wall-deficient mutant of Escherichia coli (E coli J5) to study the effect of active and passive immunization against ET in a murine model of GVHD induced by major histocompatibility antigens.
Lippincott Williams & Wilkins