Germline mutation in LKB1 is the cause of Peutz–Jeghers Syndrome in humans, a rare
disorder predisposing to cancer and multiple gastrointestinal hamartomous polyps. Mice
harboring a germline inactivating Lkb1 mutation develop similar gastrointestinal polyps and
liver neoplasia. We observed paralysis in∼ 2% of Lkb1+/− mice on two genetic
backgrounds, C57BL/6J and 129/sv, at around 300 days of age. Stepped serial sectioning of
the whole spinal column found multiple osteogenic tumours that were lobulated, showed …