COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs
JA Mitchell, TD Warner - Nature reviews Drug discovery, 2006 - nature.com
Nature reviews Drug discovery, 2006•nature.com
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the formation of prostanoids by the
enzyme cyclooxygenase (COX). Work in the past 15 years has shown that COX exists in two
forms: COX1, which is largely associated with physiological functions, and COX2, which is
largely associated with pathological functions. Heated debate followed the introduction of
selective COX2 inhibitors around 5 years ago: do these drugs offer any advantages over the
traditional NSAIDs they were meant to replace, particularly in regard to gastrointestinal and …
enzyme cyclooxygenase (COX). Work in the past 15 years has shown that COX exists in two
forms: COX1, which is largely associated with physiological functions, and COX2, which is
largely associated with pathological functions. Heated debate followed the introduction of
selective COX2 inhibitors around 5 years ago: do these drugs offer any advantages over the
traditional NSAIDs they were meant to replace, particularly in regard to gastrointestinal and …
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the formation of prostanoids by the enzyme cyclooxygenase (COX). Work in the past 15 years has shown that COX exists in two forms: COX1, which is largely associated with physiological functions, and COX2, which is largely associated with pathological functions. Heated debate followed the introduction of selective COX2 inhibitors around 5 years ago: do these drugs offer any advantages over the traditional NSAIDs they were meant to replace, particularly in regard to gastrointestinal and cardiovascular side effects? Here we discuss the evidence and the latest recommendations for the use of selective inhibitors of COX2 as well as the traditional NSAIDs.
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