[HTML][HTML] Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2
PCJ Armstrong, NJ Truss, FY Ali, AA Dhanji… - Journal of Thrombosis …, 2008 - Elsevier
Summary Background: Currently,'aspirin resistance', the anti-platelet effects of non-steroid
anti-inflammatory drugs (NSAIDs) and NSAID-aspirin interactions are hot topics of debate. It
is often held in this debate that the relationship between platelet activation and thromboxane
(TX) A 2 formation is non-linear and TXA 2 generation must be inhibited by at least 95% to
inhibit TXA 2-dependent aggregation. This relationship, however, has never been rigorously
tested. Objectives: To characterize, in vitro and ex vivo, the concentration-dependent …
anti-inflammatory drugs (NSAIDs) and NSAID-aspirin interactions are hot topics of debate. It
is often held in this debate that the relationship between platelet activation and thromboxane
(TX) A 2 formation is non-linear and TXA 2 generation must be inhibited by at least 95% to
inhibit TXA 2-dependent aggregation. This relationship, however, has never been rigorously
tested. Objectives: To characterize, in vitro and ex vivo, the concentration-dependent …