[HTML][HTML] Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling
JM Busillo, S Armando, R Sengupta, O Meucci… - Journal of biological …, 2010 - ASBMB
The chemokine receptor CXCR4 is a widely expressed G protein-coupled receptor that has
been implicated in a number of diseases including human immunodeficiency virus, cancer,
and WHIM syndrome, with the latter two involving dysregulation of CXCR4 signaling. To
better understand the role of phosphorylation in regulating CXCR4 signaling, tandem mass
spectrometry and phospho-specific antibodies were used to identify sites of agonist-
promoted phosphorylation. These studies demonstrated that Ser-321, Ser-324, Ser-325, Ser …
been implicated in a number of diseases including human immunodeficiency virus, cancer,
and WHIM syndrome, with the latter two involving dysregulation of CXCR4 signaling. To
better understand the role of phosphorylation in regulating CXCR4 signaling, tandem mass
spectrometry and phospho-specific antibodies were used to identify sites of agonist-
promoted phosphorylation. These studies demonstrated that Ser-321, Ser-324, Ser-325, Ser …