Checkpoint inhibitor-induced colitis: a new type of inflammatory bowel disease?

M Bertha, E Bellaguara, T Kuzel… - ACG case reports …, 2017 - journals.lww.com
Checkpoint inhibitors are immune-stimulatory antibodies that have transformed the
management and prognosis of individuals with metastatic melanoma and other cancers.
Checkpoint inhibitor-induced colitis is an increasingly recognized immune-related adverse
event that shares many of the same phenotypical, serological, and histological
characteristics of both Crohn's disease and ulcerative colitis, suggesting that checkpoint
inhibitor-induced colitis may represent a new inflammatory bowel disease phenotype. We …