[HTML][HTML] New insights into the regulation of T cells by γc family cytokines
Y Rochman, R Spolski, WJ Leonard - Nature Reviews Immunology, 2009 - nature.com
Y Rochman, R Spolski, WJ Leonard
Nature Reviews Immunology, 2009•nature.comCommon cytokine receptor γ-chain (γc) family cytokines have crucial roles in the
development, proliferation, survival and differentiation of multiple cell lineages of both the
innate and adaptive immune systems. In this Review, we focus on our current understanding
of the distinct and overlapping effects of interleukin-2 (IL-2), IL-7, IL-9, IL-15 and IL-21, as
well as the IL-7-related cytokine thymic stromal lymphopoietin (TSLP), on the survival and
proliferation of conventional αβ T cells, γδ T cells and regulatory T cells. This knowledge …
development, proliferation, survival and differentiation of multiple cell lineages of both the
innate and adaptive immune systems. In this Review, we focus on our current understanding
of the distinct and overlapping effects of interleukin-2 (IL-2), IL-7, IL-9, IL-15 and IL-21, as
well as the IL-7-related cytokine thymic stromal lymphopoietin (TSLP), on the survival and
proliferation of conventional αβ T cells, γδ T cells and regulatory T cells. This knowledge …
Abstract
Common cytokine receptor γ-chain (γc) family cytokines have crucial roles in the development, proliferation, survival and differentiation of multiple cell lineages of both the innate and adaptive immune systems. In this Review, we focus on our current understanding of the distinct and overlapping effects of interleukin-2 (IL-2), IL-7, IL-9, IL-15 and IL-21, as well as the IL-7-related cytokine thymic stromal lymphopoietin (TSLP), on the survival and proliferation of conventional αβ T cells, γδ T cells and regulatory T cells. This knowledge potentially allows for the therapeutic manipulation of immune responses for the treatment of cancer, autoimmunity, allergic diseases and immunodeficiency, as well as for vaccine development.
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