Aquaporin 4 expression and tissue susceptibility to neuromyelitis optica
M Matiello, J Schaefer-Klein, D Sun… - JAMA …, 2013 - jamanetwork.com
Importance To understand the predilection for optic nerve and spinal cord pathologic
changes in neuromyelitis optica (NMO). Objective To evaluate tissue-specific expression
(RNA and protein) and supramolecular aggregation of aquaporin 4 (AQP4) in mouse, rat,
and human tissues. Design Quantitative polymerase chain reaction, sodium dodecyl sulfate–
polyacrylamide gel electrophoresis, and blue native polyacrylamide gel electrophoresis.
Setting Laboratory analysis of mouse, rat, and human tissue. Participants Tissues from …
changes in neuromyelitis optica (NMO). Objective To evaluate tissue-specific expression
(RNA and protein) and supramolecular aggregation of aquaporin 4 (AQP4) in mouse, rat,
and human tissues. Design Quantitative polymerase chain reaction, sodium dodecyl sulfate–
polyacrylamide gel electrophoresis, and blue native polyacrylamide gel electrophoresis.
Setting Laboratory analysis of mouse, rat, and human tissue. Participants Tissues from …