Food-specific IgG4 is associated with eosinophilic esophagitis
BL Wright, M Kulis, R Guo, KA Orgel… - Journal of Allergy and …, 2016 - jacionline.org
The role of IgG4 in EoE is unclear. Clayton et al 2 showed that esophageal IgG4 deposits in
EoE derive from dense plasma cell infiltrates in the lamina propria. Moreover, data from one
study noted that intrasquamous deposits of IgG4 may distinguish patients with
gastroesophageal reflux disease versus EoE. 3 These observations suggest potential
associations between EoE and IgG4-related diseases. Nontheless, food-specific IgG4 (FS-
IgG 4) has also been shown to inhibit basophil and mast cell responses 4; indeed, FS-IgG4 …
EoE derive from dense plasma cell infiltrates in the lamina propria. Moreover, data from one
study noted that intrasquamous deposits of IgG4 may distinguish patients with
gastroesophageal reflux disease versus EoE. 3 These observations suggest potential
associations between EoE and IgG4-related diseases. Nontheless, food-specific IgG4 (FS-
IgG 4) has also been shown to inhibit basophil and mast cell responses 4; indeed, FS-IgG4 …