Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy
E Wambre, JH DeLong, EA James, RE LaFond… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: The main obstacle to elucidating the role of CD4+ T cells in allergen-
specific immunotherapy (SIT) has been the absence of an adequately sensitive approach to
directly characterize rare allergen-specific T cells without introducing substantial phenotypic
modifications by means of in vitro amplification. OBJECTIVE: We sought to monitor, in
physiological conditions, the allergen-specific CD4+ T cells generated during natural pollen
exposure and during allergy vaccination. METHODS: Alder pollen allergy was used as a …
specific immunotherapy (SIT) has been the absence of an adequately sensitive approach to
directly characterize rare allergen-specific T cells without introducing substantial phenotypic
modifications by means of in vitro amplification. OBJECTIVE: We sought to monitor, in
physiological conditions, the allergen-specific CD4+ T cells generated during natural pollen
exposure and during allergy vaccination. METHODS: Alder pollen allergy was used as a …