[HTML][HTML] Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

TM Fenton, A Kelly, EE Shuttleworth, C Smedley… - Mucosal …, 2017 - Elsevier
Regulation of intestinal T-cell responses is crucial for immune homeostasis and prevention
of inflammatory bowel disease (IBD). A vital cytokine in regulating intestinal T cells is
transforming growth factor-β (TGFβ), which is secreted by cells as a latent complex that
requires activation to function. However, how TGFβ activation is regulated in the human
intestine, and how such pathways are altered in IBD is completely unknown. Here we show
that a key activator of TGFβ, integrin αvβ8, is highly expressed on human intestinal dendritic …