[HTML][HTML] HLA-E expression and its clinical relevance in human renal cell carcinoma
B Seliger, S Jasinski-Bergner, D Quandt, C Stoehr… - Oncotarget, 2016 - ncbi.nlm.nih.gov
B Seliger, S Jasinski-Bergner, D Quandt, C Stoehr, J Bukur, S Wach, W Legal, H Taubert…
Oncotarget, 2016•ncbi.nlm.nih.govThe non-classical human leukocyte antigen E (HLA-E) expression is frequently
overexpressed in tumor diseases, transplants and virus-infected cells and represents an
immunomodulatory molecule by binding to the receptors CD94/NKG2A,-B and–C on NK and
T cells. Due to its immune suppressive features HLA-E expression might represent an
important mechanism of tumors to escape immune surveillance.
overexpressed in tumor diseases, transplants and virus-infected cells and represents an
immunomodulatory molecule by binding to the receptors CD94/NKG2A,-B and–C on NK and
T cells. Due to its immune suppressive features HLA-E expression might represent an
important mechanism of tumors to escape immune surveillance.
Abstract
The non-classical human leukocyte antigen E (HLA-E) expression is frequently overexpressed in tumor diseases, transplants and virus-infected cells and represents an immunomodulatory molecule by binding to the receptors CD94/NKG2A,-B and–C on NK and T cells. Due to its immune suppressive features HLA-E expression might represent an important mechanism of tumors to escape immune surveillance.
ncbi.nlm.nih.gov