[HTML][HTML] Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells
SD Rybalkin, IG Rybalkina, R Feil, F Hofmann… - Journal of Biological …, 2002 - ASBMB
Nitric oxide and endogenous nitrovasodilators regulate smooth muscle tone by elevation of
cGMP and activation of cyclic GMP-dependent protein kinase (PKG). The amplitude and
duration of the cGMP signal in smooth muscle is regulated in large part by cGMP-specific
cyclic nucleotide phosphodiesterase (PDE5). Previous in vitro data have suggested that
both cAMP-dependent protein kinase and PKG can regulate the activity of PDE5. To test if
this type of regulation is important in the intact cell, we have generated phospho-PDE5 …
cGMP and activation of cyclic GMP-dependent protein kinase (PKG). The amplitude and
duration of the cGMP signal in smooth muscle is regulated in large part by cGMP-specific
cyclic nucleotide phosphodiesterase (PDE5). Previous in vitro data have suggested that
both cAMP-dependent protein kinase and PKG can regulate the activity of PDE5. To test if
this type of regulation is important in the intact cell, we have generated phospho-PDE5 …