Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse

SF Hassnain Waqas, A Noble, AC Hoang… - Journal of leukocyte …, 2017 - academic.oup.com
SF Hassnain Waqas, A Noble, AC Hoang, G Ampem, M Popp, S Strauß, M Guille, T Röszer
Journal of leukocyte biology, 2017academic.oup.com
ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT
inflammation. The control of the ATM number may have therapeutic potential; however,
information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from
circulating monocytes, various tissue-resident Mϕs are capable of self-renewal and develop
from BM-independent progenitors without a monocyte intermediate. Here, we show that
amphibian AT contains self-renewing ATMs that populate the AT before the establishment of …
Abstract
ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue-resident Mϕs are capable of self-renewal and develop from BM-independent progenitors without a monocyte intermediate. Here, we show that amphibian AT contains self-renewing ATMs that populate the AT before the establishment of BM hematopoiesis. Xenopus ATMs develop from progenitors of aVBI. In the mouse, a significant amount of ATM develops from the yolk sac, the mammalian equivalent of aVBI. In summary, this study provides evidence for a prenatal origin of ATMs and shows that the study of amphibian ATMs can enhance the understanding of the role of the prenatal environment in ATM development.
Oxford University Press