[HTML][HTML] Group X secreted phospholipase A2 releases ω3 polyunsaturated fatty acids, suppresses colitis, and promotes sperm fertility

R Murase, H Sato, K Yamamoto, A Ushida… - Journal of Biological …, 2016 - ASBMB
Within the secreted phospholipase A 2 (sPLA 2) family, group X sPLA 2 (sPLA 2-X) has the
highest capacity to hydrolyze cellular membranes and has long been thought to promote
inflammation by releasing arachidonic acid, a precursor of pro-inflammatory eicosanoids.
Unexpectedly, we found that transgenic mice globally overexpressing human sPLA 2-X
(PLA2G10-Tg) displayed striking immunosuppressive and lean phenotypes with
lymphopenia and increased M2-like macrophages, accompanied by marked elevation of …