Involvement of oxidative stress in taxol-induced apoptosis in chronic myelogenous leukemia K562 cells
A Meshkini, R Yazdanparast - Experimental and toxicologic pathology, 2012 - Elsevier
It is now well accepted that taxol exhibits cytotoxicity and antitumor activity in many human
tumors through microtubule stabilization and induction of G2/M cell cycle arrest with final
extensive cell apoptosis. Since many anti-cancer agents exert their cytotoxic effects through
reactive oxygen species (ROS), we were interested to evaluate whether oxidative stress is
involved in taxol-induced cytotoxicity among human leukemia K562 cells. Our results
showed that induction of apoptosis was associated with generation of ROS and glutathione …
tumors through microtubule stabilization and induction of G2/M cell cycle arrest with final
extensive cell apoptosis. Since many anti-cancer agents exert their cytotoxic effects through
reactive oxygen species (ROS), we were interested to evaluate whether oxidative stress is
involved in taxol-induced cytotoxicity among human leukemia K562 cells. Our results
showed that induction of apoptosis was associated with generation of ROS and glutathione …