[HTML][HTML] The inextricable role of the kidney in hypertension

SD Crowley, TM Coffman - The Journal of clinical …, 2014 - Am Soc Clin Investig
SD Crowley, TM Coffman
The Journal of clinical investigation, 2014Am Soc Clin Investig
An essential link between the kidney and blood pressure control has long been known.
Here, we review evidence supporting the premise that an impaired capacity of the kidney to
excrete sodium in response to elevated blood pressure is a major contributor to
hypertension, irrespective of the initiating cause. In this regard, recent work suggests that
novel pathways controlling key sodium transporters in kidney epithelia have a critical impact
on hypertension pathogenesis, supporting a model in which impaired renal sodium …
An essential link between the kidney and blood pressure control has long been known. Here, we review evidence supporting the premise that an impaired capacity of the kidney to excrete sodium in response to elevated blood pressure is a major contributor to hypertension, irrespective of the initiating cause. In this regard, recent work suggests that novel pathways controlling key sodium transporters in kidney epithelia have a critical impact on hypertension pathogenesis, supporting a model in which impaired renal sodium excretion is a final common pathway through which vascular, neural, and inflammatory responses raise blood pressure. We also address recent findings calling into question long-standing notions regarding the relationship between sodium intake and changes in body fluid volume. Expanded understanding of the role of the kidney as both a cause and target of hypertension highlights key aspects of pathophysiology and may lead to identification of new strategies for prevention and treatment.
The Journal of Clinical Investigation