[HTML][HTML] The rise and fall of the thiazolidinediones: impact of clinical evidence publication and formulary change on the prescription incidence of thiazolidinediones
S Hashim, T Gomes, D Juurlink, C Hellings… - Journal of Population …, 2013 - jptcp.com
S Hashim, T Gomes, D Juurlink, C Hellings, M Mamdani
Journal of Population Therapeutics and Clinical Pharmacology, 2013•jptcp.comBackground Numerous factors affect drug utilization including clinical trials, promotional
activity, drug safety signals and funding practices. We sought to investigate the impact of
cardiovascular safety concerns and public drug formulary restrictions on the use of the
thiazolidinediones (TZDs): rosiglitazone and pioglitazone. Methods We conducted a
population-based cross-sectional time series analysis among more than 1.6 million older
residents of Ontario, Canada using administrative healthcare claims databases from …
activity, drug safety signals and funding practices. We sought to investigate the impact of
cardiovascular safety concerns and public drug formulary restrictions on the use of the
thiazolidinediones (TZDs): rosiglitazone and pioglitazone. Methods We conducted a
population-based cross-sectional time series analysis among more than 1.6 million older
residents of Ontario, Canada using administrative healthcare claims databases from …
Abstract
Background
Numerous factors affect drug utilization including clinical trials, promotional activity, drug safety signals and funding practices. We sought to investigate the impact of cardiovascular safety concerns and public drug formulary restrictions on the use of the thiazolidinediones (TZDs): rosiglitazone and pioglitazone.
Methods
We conducted a population-based cross-sectional time series analysis among more than 1.6 million older residents of Ontario, Canada using administrative healthcare claims databases from January 2000 to September 2010 to examine the impact of two events on the rate of initiation of TZDs among those aged
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