Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
JG Kim, S Suyama, M Koch, S Jin… - Nature …, 2014 - nature.com
Nature neuroscience, 2014•nature.com
We found that leptin receptors were expressed in hypothalamic astrocytes and that their
conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic
neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas
feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific
leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic
synaptic remodeling and control of feeding by leptin.
conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic
neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas
feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific
leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic
synaptic remodeling and control of feeding by leptin.
Abstract
We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.
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