Head and neck squamous cell carcinoma cell lines: established models and rationale for selection
CJ Lin, JR Grandis, TE Carey, SM Gollin… - Head & Neck …, 2007 - Wiley Online Library
CJ Lin, JR Grandis, TE Carey, SM Gollin, TL Whiteside, WM Koch, RL Ferris, SY Lai
Head & Neck: Journal for the Sciences and Specialties of the Head …, 2007•Wiley Online LibraryBackground. Head and neck squamous cell carcinoma (HNSCC) cell lines are important
preclinical models in the search for novel and targeted therapies to treat head and neck
cancer. Unlike many other cancer types, a wide variety of primary and metastatic HNSCC
cell lines are available. An easily accessible guide that organizes important characteristics
of HNSCC cell lines would be valuable for the selection of appropriate HNSCC cell lines for
in vitro or in vivo studies. Methods. A literature search was performed. Results. Cell growth …
preclinical models in the search for novel and targeted therapies to treat head and neck
cancer. Unlike many other cancer types, a wide variety of primary and metastatic HNSCC
cell lines are available. An easily accessible guide that organizes important characteristics
of HNSCC cell lines would be valuable for the selection of appropriate HNSCC cell lines for
in vitro or in vivo studies. Methods. A literature search was performed. Results. Cell growth …
Background
Head and neck squamous cell carcinoma (HNSCC) cell lines are important preclinical models in the search for novel and targeted therapies to treat head and neck cancer. Unlike many other cancer types, a wide variety of primary and metastatic HNSCC cell lines are available. An easily accessible guide that organizes important characteristics of HNSCC cell lines would be valuable for the selection of appropriate HNSCC cell lines for in vitro or in vivo studies.
Methods
A literature search was performed.
Results
Cell growth and culture parameters from HNSCC cell lines were catalogued into tables or lists of selected characteristics. Methods for establishing cancer cell lines and basic cell culture maintenance techniques were reviewed.
Conclusions
A compendium of HNSCC cell line characteristics is useful for organizing the accumulating information regarding cell line characteristics to assist investigators with the development of appropriate preclinical models. © 2006 Wiley Periodicals, Inc. Head Neck, 2006
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