Sequenced treatment alternatives to relieve depression (STAR* D): rationale and design
STAR* D is a multisite, prospective, randomized, multistep clinical trial of outpatients with
nonpsychotic major depressive disorder. The study compares various treatment options for
those who do not attain a satisfactory response with citalopram, a selective serotonin
reuptake inhibitor antidepressant. The study enrolls 4000 adults (ages 18–75) from both
primary and specialty care practices who have not had either a prior inadequate response or
clear-cut intolerance to a robust trial of protocol treatments during the current major …
nonpsychotic major depressive disorder. The study compares various treatment options for
those who do not attain a satisfactory response with citalopram, a selective serotonin
reuptake inhibitor antidepressant. The study enrolls 4000 adults (ages 18–75) from both
primary and specialty care practices who have not had either a prior inadequate response or
clear-cut intolerance to a robust trial of protocol treatments during the current major …