[HTML][HTML] Immune defence against Candida fungal infections

MG Netea, LAB Joosten, JWM Van Der Meer… - Nature Reviews …, 2015 - nature.com
MG Netea, LAB Joosten, JWM Van Der Meer, BJ Kullberg, FL Van De Veerdonk
Nature Reviews Immunology, 2015nature.com
The immune response to Candida species is shaped by the commensal character of the
fungus. There is a crucial role for discerning between colonization and invasion at mucosal
surfaces, with the antifungal host defence mechanisms used during mucosal or systemic
infection with Candida species differing substantially. Here, we describe how innate sensing
of fungi by pattern recognition receptors and the interplay of immune cells (both myeloid and
lymphoid) with non-immune cells, including platelets and epithelial cells, shapes host …
Abstract
The immune response to Candida species is shaped by the commensal character of the fungus. There is a crucial role for discerning between colonization and invasion at mucosal surfaces, with the antifungal host defence mechanisms used during mucosal or systemic infection with Candida species differing substantially. Here, we describe how innate sensing of fungi by pattern recognition receptors and the interplay of immune cells (both myeloid and lymphoid) with non-immune cells, including platelets and epithelial cells, shapes host immunity to Candida species. Furthermore, we discuss emerging data suggesting that both the innate and adaptive immune systems display memory characteristics after encountering Candida species.
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