[PDF][PDF] Clearance of hepatitis B surface antigen after bone marrow transplantation: role of adoptive immunity transfer

GK Lau, AS Lok, RH Liang, CL Lai, EK Chiu… - …, 1997 - Wiley Online Library
GK Lau, AS Lok, RH Liang, CL Lai, EK Chiu, YL Lau, SK Lam
Hepatology, 1997Wiley Online Library
Adoptive immunity transfer has been reported to be effective in clearing chronic hepatitis B
virus (HBV) infection. Two hundred twenty‐six patients who received allogeneic bone
marrow transplantation (BMT) between May 1990 and September 1995 were screened for
hepatitis B markers. Twenty‐one patients were hepatitis B surface antigen (HBsAg) positive
before BMT. The median follow‐up period was 20 months (range, 2‐59 months). Two of
these patients had sustained clearance of HBV infection after transplantation. Both patients …
Abstract
Adoptive immunity transfer has been reported to be effective in clearing chronic hepatitis B virus (HBV) infection. Two hundred twenty‐six patients who received allogeneic bone marrow transplantation (BMT) between May 1990 and September 1995 were screened for hepatitis B markers. Twenty‐one patients were hepatitis B surface antigen (HBsAg) positive before BMT. The median follow‐up period was 20 months (range, 2‐59 months). Two of these patients had sustained clearance of HBV infection after transplantation. Both patients were hepatitis B e antigen (HBeAg)‐negative, hepatitis B e antibody (anti‐HBe)‐positive, and serum HBV DNA‐negative (by dot‐blot hybridization) before BMT. Both had a flare in the serum alanine transaminase (ALT) level around the time of HBsAg clearance. Sustained clearance of HBsAg was observed in 2 of the 5 patients who received hepatitis B surface antibody (anti‐HBs)‐positive marrow but in none of the 16 patients who received anti‐HBs‐negative marrow (P < .05). One additional patient who received anti‐HBs‐positive marrow had transient HBsAg seroconversion. Among the 18 patients who remained persistently HBsAg‐positive after BMT, 3 had HBeAg seroconversion and 3 had reversion to HBeAg positivity. In this study, we found a significant association between clearance of HBV infection and anti‐HBs‐positive bone marrow donors. Adoptive immunity transfer is effective in clearing HBV from patients with chronic HBV infection.
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