[HTML][HTML] Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology
CR Chang, C Blackstone - Journal of Biological Chemistry, 2007 - ASBMB
Mitochondria in cells comprise a tubulovesicular reticulum shaped by dynamic fission and
fusion events. The multimeric dynamin-like GTPase Drp1 is a critical protein mediating
mitochondrial division. It harbors multiple motifs including GTP-binding, middle, and GTPase
effector (GED) domains that are important for both intramolecular and intermolecular
interactions. As for other members of the dynamin superfamily, such interactions are critical
for assembly of higher-order structures and cooperative increases in GTPase activity …
fusion events. The multimeric dynamin-like GTPase Drp1 is a critical protein mediating
mitochondrial division. It harbors multiple motifs including GTP-binding, middle, and GTPase
effector (GED) domains that are important for both intramolecular and intermolecular
interactions. As for other members of the dynamin superfamily, such interactions are critical
for assembly of higher-order structures and cooperative increases in GTPase activity …