Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease

TJ Wilson, AM Slupe, S Strack - Neurobiology of disease, 2013 - Elsevier
TJ Wilson, AM Slupe, S Strack
Neurobiology of disease, 2013Elsevier
Nascent evidence indicates that mitochondrial fission, fusion, and transport are subject to
intricate regulatory mechanisms that intersect with both well-characterized and emerging
signaling pathways. While it is well established that mutations in components of the
mitochondrial fission/fusion machinery can cause neurological disorders, relatively little is
known about upstream regulators of mitochondrial dynamics and their role in
neurodegeneration. Here, we review posttranslational regulation of mitochondrial …
Nascent evidence indicates that mitochondrial fission, fusion, and transport are subject to intricate regulatory mechanisms that intersect with both well-characterized and emerging signaling pathways. While it is well established that mutations in components of the mitochondrial fission/fusion machinery can cause neurological disorders, relatively little is known about upstream regulators of mitochondrial dynamics and their role in neurodegeneration. Here, we review posttranslational regulation of mitochondrial fission/fusion enzymes, with particular emphasis on dynamin-related protein 1 (Drp1), as well as outer mitochondrial signaling complexes involving protein kinases and phosphatases. We also review recent evidence that mitochondrial dynamics has profound consequences for neuronal development and synaptic transmission and discuss implications for clinical translation.
Elsevier