[HTML][HTML] The INs and OUTs of mitofusins
M Giacomello, L Scorrano - The Journal of Cell Biology, 2018 - ncbi.nlm.nih.gov
M Giacomello, L Scorrano
The Journal of Cell Biology, 2018•ncbi.nlm.nih.govMitofusins are outer membrane proteins essential for mitochondrial fusion. Their accepted
topology posits that both N and C termini face the cytoplasm. In this issue, Mattie et al.(2018.
J. Cell Biol. https://doi. org/10.1083/jcb. 201611194) demonstrate instead that their C termini
reside in the intermembrane space. These findings call for a revision of the current models of
mitochondrial fusion.
topology posits that both N and C termini face the cytoplasm. In this issue, Mattie et al.(2018.
J. Cell Biol. https://doi. org/10.1083/jcb. 201611194) demonstrate instead that their C termini
reside in the intermembrane space. These findings call for a revision of the current models of
mitochondrial fusion.
Abstract
Mitofusins are outer membrane proteins essential for mitochondrial fusion. Their accepted topology posits that both N and C termini face the cytoplasm. In this issue, Mattie et al.(2018. J. Cell Biol. https://doi. org/10.1083/jcb. 201611194) demonstrate instead that their C termini reside in the intermembrane space. These findings call for a revision of the current models of mitochondrial fusion.
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