[HTML][HTML] Role of IL-35 in sublingual allergen immunotherapy
MH Shamji, JA Layhadi, D Achkova, L Kouser… - Journal of Allergy and …, 2019 - Elsevier
Background Grass pollen–specific immunotherapy involves immunomodulation of allergen-
specific TH 2 responses and induction of IL-10+ and/or TGF-β+ CD4+ CD25+ regulatory T
cells (induced Treg cells). IL-35+ CD4+ CD25+ forkhead box protein 3–negative T (IL-35–
inducible regulatory T [iT R 35]) cells have been reported as a novel subset of induced Treg
cells with modulatory characteristics. Objective We sought to investigate mechanisms
underlying the induction and maintenance of immunologic tolerance induced by IL-35 and iT …
specific TH 2 responses and induction of IL-10+ and/or TGF-β+ CD4+ CD25+ regulatory T
cells (induced Treg cells). IL-35+ CD4+ CD25+ forkhead box protein 3–negative T (IL-35–
inducible regulatory T [iT R 35]) cells have been reported as a novel subset of induced Treg
cells with modulatory characteristics. Objective We sought to investigate mechanisms
underlying the induction and maintenance of immunologic tolerance induced by IL-35 and iT …