A dose-response comparison between methadone and morphine self-administration
TE Werner, SG Smith, WM Davis - Psychopharmacology, 1976 - Springer
TE Werner, SG Smith, WM Davis
Psychopharmacology, 1976•SpringerRats were allowed to self-administer a solution of 0.9% saline, or 0.01, 0.03, 0.1 or 0.3
mg/kg/infusion of methadone hydrochloride or 0.03, 0.1 or 0.3 mg/kg/infusion of morphine
sulfate. The results showed that number of infusions taken was an inverse function of unit
dose, while amount of drug self-administered (mg/kg) was a direct function of unit dose. The
data also indicated that more morphine than methadone was self-administered.
mg/kg/infusion of methadone hydrochloride or 0.03, 0.1 or 0.3 mg/kg/infusion of morphine
sulfate. The results showed that number of infusions taken was an inverse function of unit
dose, while amount of drug self-administered (mg/kg) was a direct function of unit dose. The
data also indicated that more morphine than methadone was self-administered.
Abstract
Rats were allowed to self-administer a solution of 0.9% saline, or 0.01, 0.03, 0.1 or 0.3 mg/kg/infusion of methadone hydrochloride or 0.03, 0.1 or 0.3 mg/kg/infusion of morphine sulfate. The results showed that number of infusions taken was an inverse function of unit dose, while amount of drug self-administered (mg/kg) was a direct function of unit dose. The data also indicated that more morphine than methadone was self-administered.
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