Partial deficiencies of erythrocyte spectrin in hereditary spherocytosis
P Agre - Red Blood Cell Membranes, 2020 - taylorfrancis.com
Red Blood Cell Membranes, 2020•taylorfrancis.com
Hereditary spherocytosis is a congenital hemolytic anemia that has been a longstanding
puzzle to hematologists and geneticists (see recent reviews [1–3]). It is a common disorder
affecting~ 1 in 5000 individuals of Northern European ancestry [4]. The genetic defect is
incompletely defined but results in erythrocytes that are abnormally fragile and become
increasingly spherical rather than retaining the normal biconcave disk shape.
puzzle to hematologists and geneticists (see recent reviews [1–3]). It is a common disorder
affecting~ 1 in 5000 individuals of Northern European ancestry [4]. The genetic defect is
incompletely defined but results in erythrocytes that are abnormally fragile and become
increasingly spherical rather than retaining the normal biconcave disk shape.
Hereditary spherocytosis is a congenital hemolytic anemia that has been a longstanding puzzle to hematologists and geneticists (see recent reviews [1–3]). It is a common disorder affecting ~1 in 5000 individuals of Northern European ancestry [4]. The genetic defect is incompletely defined but results in erythrocytes that are abnormally fragile and become increasingly spherical rather than retaining the normal biconcave disk shape.
taylorfrancis.com