Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection
MS Sulkowski, DL Thomas, RE Chaisson, RD Moore - Jama, 2000 - jamanetwork.com
ContextUse of antiretroviral drugs, including protease inhibitors, for treatment of human
immunodeficiency virus (HIV) infection has been anecdotally associated with hepatotoxicity,
particularly in persons coinfected with hepatitis C or B virus. ObjectivesTo ascertain if
incidence of severe hepatotoxicity during antiretroviral therapy is similar for all antiretroviral
drug combinations, and to define the role of chronic viral hepatitis in its development.
DesignProspective cohort study. SettingUniversity-based urban HIV clinic. PatientsA total of …
immunodeficiency virus (HIV) infection has been anecdotally associated with hepatotoxicity,
particularly in persons coinfected with hepatitis C or B virus. ObjectivesTo ascertain if
incidence of severe hepatotoxicity during antiretroviral therapy is similar for all antiretroviral
drug combinations, and to define the role of chronic viral hepatitis in its development.
DesignProspective cohort study. SettingUniversity-based urban HIV clinic. PatientsA total of …