Since the introduction of mobilized peripheral blood stem cells for transplantation purposes,
many studies have been performed using mobilized cells with different mobilization
schemes, primarily to optimize mobilization protocols. Studies aiming at mechanisms of
mobilization have been few, but have provided useful insights. However, conclusions about
mobilization mechanisms were largely inferential. We have attempted to analyze the
mobilization process involving the VLA-4/VCAM-1 pathway. Our findings are summarized …