Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
RA Morgan, N Chinnasamy, D Abate-Daga… - Journal of …, 2013 - journals.lww.com
Nine cancer patients were treated with adoptive cell therapy using autologous anti-MAGE-
A3 T-cell receptors (TCR)-engineered T cells. Five patients experienced clinical regression
of their cancers including 2 on-going responders. Beginning 1–2 days postinfusion, 3
patients (#'s 5, 7, and 8) experienced mental status changes, and 2 patients (5 and 8) lapsed
into comas and subsequently died. Magnetic resonance imagining analysis of patients 5
and 8 demonstrated periventricular leukomalacia, and examination of their brains at autopsy …
A3 T-cell receptors (TCR)-engineered T cells. Five patients experienced clinical regression
of their cancers including 2 on-going responders. Beginning 1–2 days postinfusion, 3
patients (#'s 5, 7, and 8) experienced mental status changes, and 2 patients (5 and 8) lapsed
into comas and subsequently died. Magnetic resonance imagining analysis of patients 5
and 8 demonstrated periventricular leukomalacia, and examination of their brains at autopsy …