Expression and purification of soluble porcine CTLA-4 in yeast Pichia pastoris
J Peraino, H Zhang, CE Hermanrud, G Li… - Protein expression and …, 2012 - Elsevier
Co-stimulation blockade can be used to modulate the immune response for induction of
organ transplantation tolerance, treatment of autoimmune disease as well as cancer
treatment. Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152, is an
important co-stimulatory molecule which serves as a negative regulator for T cell
proliferation and differentiation. CTLA-4/CD28-CD80/CD86 pathway is a critical co-
stimulatory pathway for adaptive immune response. T cell activation through the T cell …
organ transplantation tolerance, treatment of autoimmune disease as well as cancer
treatment. Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152, is an
important co-stimulatory molecule which serves as a negative regulator for T cell
proliferation and differentiation. CTLA-4/CD28-CD80/CD86 pathway is a critical co-
stimulatory pathway for adaptive immune response. T cell activation through the T cell …