Excitatory amino acids as a final common pathway for neurologic disorders
SA Lipton, PA Rosenberg - New England Journal of Medicine, 1994 - Mass Medical Soc
SA Lipton, PA Rosenberg
New England Journal of Medicine, 1994•Mass Medical SocIn many neurologic disorders, injury to neurons may be caused at least in part by
overstimulation of receptors for excitatory amino acids, including glutamate and aspartate.
These neurologic conditions range from acute insults such as stroke, hypoglycemia, trauma,
and epilepsy (Table 1) to chronic neurodegenerative states such as Huntington's disease,
the acquired immunodeficiency syndrome (AIDS) dementia complex, amyotrophic lateral
sclerosis, and perhaps Alzheimer's disease (Table 2) 1–3. Glutamate is the principal …
overstimulation of receptors for excitatory amino acids, including glutamate and aspartate.
These neurologic conditions range from acute insults such as stroke, hypoglycemia, trauma,
and epilepsy (Table 1) to chronic neurodegenerative states such as Huntington's disease,
the acquired immunodeficiency syndrome (AIDS) dementia complex, amyotrophic lateral
sclerosis, and perhaps Alzheimer's disease (Table 2) 1–3. Glutamate is the principal …
In many neurologic disorders, injury to neurons may be caused at least in part by overstimulation of receptors for excitatory amino acids, including glutamate and aspartate. These neurologic conditions range from acute insults such as stroke, hypoglycemia, trauma, and epilepsy (Table 1) to chronic neurodegenerative states such as Huntington's disease, the acquired immunodeficiency syndrome (AIDS) dementia complex, amyotrophic lateral sclerosis, and perhaps Alzheimer's disease (Table 2)1–3.
Glutamate is the principal excitatory neurotransmitter in the brain, and its interactions with specific membrane receptors are responsible for many neurologic functions, including cognition, memory, movement, and sensation4. In addition, excitatory . . .
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