The kidneys are highly metabolic organs that produce vast quantities of adenosine
triphosphate via oxidative phosphorylation and, as such, contain many mitochondria.
Although mitochondrial reactive oxygen species are involved in many physiological
processes in the kidneys, there is a plethora of evidence to suggest that excessive
production may be a pathologic mediator of many chronic kidney diseases, including
diabetic kidney disease. Despite this, results from clinical testing of antioxidant therapies …