[HTML][HTML] The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro

JM Spatz, MN Wein, JH Gooi, Y Qu, JL Garr… - Journal of Biological …, 2015 - ASBMB
Although bone responds to its mechanical environment, the cellular and molecular
mechanisms underlying the response of the skeleton to mechanical unloading are not
completely understood. Osteocytes are the most abundant but least understood cells in
bones and are thought to be responsible for sensing stresses and strains in bone.
Sclerostin, a product of the SOST gene, is produced postnatally primarily by osteocytes and
is a negative regulator of bone formation. Recent studies show that SOST is mechanically …