[HTML][HTML] Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-β1 activity in endothelial cells

K Boström, AF Zebboudj, Y Yao, TS Lin… - Journal of Biological …, 2004 - ASBMB
Matrix GLA protein (MGP) is expressed in endothelial cells (EC), and MGP deficiency results
in developmental defects suggesting involvement in EC function. To determine the role of
MGP in EC, we cultured bovine aortic EC with increasing concentrations of human MGP
(hMGP) for 24 h. The results showed increased proliferation, migration, tube formation, and
increased release of vascular endothelial growth factor-A (VEGF-A) and basic fibroblast
growth factor (bFGF). HMGP, added endogenously or transiently expressed, increased …