A mathematical model of Ca2+ dynamics in rat mesenteric smooth muscle cell: agonist and NO stimulation
A Kapela, A Bezerianos, NM Tsoukias - Journal of theoretical biology, 2008 - Elsevier
A mathematical model of calcium dynamics in vascular smooth muscle cell (SMC) was
developed based on data mostly from rat mesenteric arterioles. The model focuses on (a)
the plasma membrane electrophysiology;(b) Ca2+ uptake and release from the
sarcoplasmic reticulum (SR);(c) cytosolic balance of Ca2+, Na+, K+, and Cl− ions; and (d)
IP3 and cGMP formation in response to norepinephrine (NE) and nitric oxide (NO)
stimulation. Stimulation with NE induced membrane depolarization and an intracellular …
developed based on data mostly from rat mesenteric arterioles. The model focuses on (a)
the plasma membrane electrophysiology;(b) Ca2+ uptake and release from the
sarcoplasmic reticulum (SR);(c) cytosolic balance of Ca2+, Na+, K+, and Cl− ions; and (d)
IP3 and cGMP formation in response to norepinephrine (NE) and nitric oxide (NO)
stimulation. Stimulation with NE induced membrane depolarization and an intracellular …