[HTML][HTML] Adenylyl cyclase anchoring by a kinase anchor protein AKAP5 (AKAP79/150) is important for postsynaptic β-adrenergic signaling

M Zhang, T Patriarchi, IS Stein, H Qian, L Matt… - Journal of Biological …, 2013 - ASBMB
Recent evidence indicates that the A kinase anchor protein AKAP5 (AKAP79/150) interacts
not only with PKA but also with various adenylyl cyclase (AC) isoforms. However, the
physiological relevance of AC-AKAP5 binding is largely unexplored. We now show that
postsynaptic targeting of AC by AKAP5 is important for phosphorylation of the AMPA-type
glutamate receptor subunit GluA1 on Ser-845 by PKA and for synaptic plasticity.
Phosphorylation of GluA1 on Ser-845 is strongly reduced (by 70%) under basal conditions …