[HTML][HTML] Protein phosphatase 2A is associated with class C L-type calcium channels (Cav1. 2) and antagonizes channel phosphorylation by cAMP-dependent protein …
Phosphorylation by cAMP-dependent protein kinase (PKA) regulates a vast number of
cellular functions. An important target for PKA in brain and heart is the class CL-type Ca 2+
channel (Ca v 1.2). PKA phosphorylates serine 1928 in the central, pore-forming α 1C
subunit of this channel. Regulation of channel activity by PKA requires a proper balance
between phosphorylation and dephosphorylation. For fast and specific signaling, PKA is
recruited to this channel by an protein kinase A anchor protein (Davare, MA, Dong, F …
cellular functions. An important target for PKA in brain and heart is the class CL-type Ca 2+
channel (Ca v 1.2). PKA phosphorylates serine 1928 in the central, pore-forming α 1C
subunit of this channel. Regulation of channel activity by PKA requires a proper balance
between phosphorylation and dephosphorylation. For fast and specific signaling, PKA is
recruited to this channel by an protein kinase A anchor protein (Davare, MA, Dong, F …