Implications of obesity for drug therapy: limitations and challenges
Clinical Pharmacology & Therapeutics, 2011•Wiley Online Library
Obesity has become a worldwide challenge with significant health and socioeconomic
implications. One of the major implications is its impact on drug therapy. In order to gain a
better understanding of this impact, we surveyed the regulatory guidances, the newly
approved molecular entity drug products, and drug product labels in the Physician's Desk
Reference. This review summarizes the findings of the survey along with the existing
knowledge on pharmacokinetic and pharmacodynamic changes associated with obesity …
implications. One of the major implications is its impact on drug therapy. In order to gain a
better understanding of this impact, we surveyed the regulatory guidances, the newly
approved molecular entity drug products, and drug product labels in the Physician's Desk
Reference. This review summarizes the findings of the survey along with the existing
knowledge on pharmacokinetic and pharmacodynamic changes associated with obesity …
Obesity has become a worldwide challenge with significant health and socioeconomic implications. One of the major implications is its impact on drug therapy. In order to gain a better understanding of this impact, we surveyed the regulatory guidances, the newly approved molecular entity drug products, and drug product labels in the Physician's Desk Reference. This review summarizes the findings of the survey along with the existing knowledge on pharmacokinetic and pharmacodynamic changes associated with obesity.
Clinical Pharmacology & Therapeutics (2011) 90 1, 77–89. doi:10.1038/clpt.2011.104
Wiley Online Library