Inhibiting fatty acid oxidation blocks tumour growth
S Crunkhorn - Nature Reviews Drug Discovery, 2016 - nature.com
S Crunkhorn
Nature Reviews Drug Discovery, 2016•nature.comExpression of the oncogenic transcription factor MYC is increased in triple-negative breast
cancer (TNBC). Although MYC has been shown to alter metabolism during tumorigenesis,
the role of MYC in TNBC metabolism has not been established. Camarda et al. now report
that fatty acid oxidation (FAO) is upregulated in a mouse model of MYC-overexpressing
TNBC, as well as in tumours from patients with breast cancer. Inhibition of FAO, using the
carnitine palmitoyltransferase 1 inhibitor etomoxir, blocked tumour growth in both a MYC …
cancer (TNBC). Although MYC has been shown to alter metabolism during tumorigenesis,
the role of MYC in TNBC metabolism has not been established. Camarda et al. now report
that fatty acid oxidation (FAO) is upregulated in a mouse model of MYC-overexpressing
TNBC, as well as in tumours from patients with breast cancer. Inhibition of FAO, using the
carnitine palmitoyltransferase 1 inhibitor etomoxir, blocked tumour growth in both a MYC …
Expression of the oncogenic transcription factor MYC is increased in triple-negative breast cancer (TNBC). Although MYC has been shown to alter metabolism during tumorigenesis, the role of MYC in TNBC metabolism has not been established. Camarda et al. now report that fatty acid oxidation (FAO) is upregulated in a mouse model of MYC-overexpressing TNBC, as well as in tumours from patients with breast cancer. Inhibition of FAO, using the carnitine palmitoyltransferase 1 inhibitor etomoxir, blocked tumour growth in both a MYC-driven transgenic TNBC mouse model and in a patient-derived xenograft model of MYC-overexpressing TNBC.
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