Autoimmune hepatitis–update 2015

MP Manns, AW Lohse, D Vergani - Journal of hepatology, 2015 - journal-of-hepatology.eu
Autoimmune hepatitis (AIH) was first described in 1951 [1] as a chronic hepatitis of young
women with hypergammaglobulinemia in the absence of cirrhosis, which responds well to
adrenocorticotrophic therapy (ACTH). Shortly thereafter this syndrome was described and
characterized in the USA. In 1956 the association with anti-nuclear antibodies (ANA) was
discovered and the term ''lupoid hepatitis''was created [2]. AIH and systemic lupus
erythematosus (SLE) are distinct autoimmune disorders. However, they may occur together …