Evidence for type II cells as cells of origin of K-Ras–induced distal lung adenocarcinoma
Proceedings of the National Academy of Sciences, 2012•National Acad Sciences
Identifying the cells of origin of lung cancer may lead to new therapeutic strategies. Previous
work has focused upon the putative bronchoalveolar stem cell at the bronchioalveolar duct
junction as a cancer cell of origin when a codon 12 K-Ras mutant is induced via adenoviral
Cre inhalation. In the present study, we use two “knock-in” Cre-estrogen receptor alleles to
inducibly express K-RasG12D in CC10+ epithelial cells and Sftpc+ type II alveolar cells of
the adult mouse lung. Analysis of these mice identifies type II cells, Clara cells in the terminal …
work has focused upon the putative bronchoalveolar stem cell at the bronchioalveolar duct
junction as a cancer cell of origin when a codon 12 K-Ras mutant is induced via adenoviral
Cre inhalation. In the present study, we use two “knock-in” Cre-estrogen receptor alleles to
inducibly express K-RasG12D in CC10+ epithelial cells and Sftpc+ type II alveolar cells of
the adult mouse lung. Analysis of these mice identifies type II cells, Clara cells in the terminal …
Identifying the cells of origin of lung cancer may lead to new therapeutic strategies. Previous work has focused upon the putative bronchoalveolar stem cell at the bronchioalveolar duct junction as a cancer cell of origin when a codon 12 K-Ras mutant is induced via adenoviral Cre inhalation. In the present study, we use two “knock-in” Cre-estrogen receptor alleles to inducibly express K-RasG12D in CC10+ epithelial cells and Sftpc+ type II alveolar cells of the adult mouse lung. Analysis of these mice identifies type II cells, Clara cells in the terminal bronchioles, and putative bronchoalveolar stem cells as cells of origin for K-Ras–induced lung hyperplasia. However, only type II cells appear to progress to adenocarcinoma.
National Acad Sciences