[HTML][HTML] HDAC3 and HDAC7 have opposite effects on osteoclast differentiation
L Pham, B Kaiser, A Romsa, T Schwarz… - Journal of Biological …, 2011 - ASBMB
Histone deacetylases (HDACs) are negative regulators of transcription. Endochondral bone
formation including chondrocyte and osteoblast maturation is regulated by HDACs. Very
little is known about the role HDACs play in osteoclast differentiation. It has been previously
reported that HDAC inhibitors, trichostatin A and sodium butyrate, suppress osteoclast
differentiation through multiple mechanisms. In this study, we report that suppression of
HDAC3 expression similar to HDAC inhibitors inhibits osteoclast differentiation, whereas …
formation including chondrocyte and osteoblast maturation is regulated by HDACs. Very
little is known about the role HDACs play in osteoclast differentiation. It has been previously
reported that HDAC inhibitors, trichostatin A and sodium butyrate, suppress osteoclast
differentiation through multiple mechanisms. In this study, we report that suppression of
HDAC3 expression similar to HDAC inhibitors inhibits osteoclast differentiation, whereas …